STE20 — Aspergillus fumigatus

Summary

AFU2G10460 (STE20, also known as TSC11 or AfSTE20) in Aspergillus fumigatus encodes a putative cytosolic regulator Pianissimo. The protein contains Rictor and Pianissimo family domains, including ARM-type and HR1 rho-binding folds. It is associated with TORC2 signaling, wound healing, inflammatory response, cellular response to starvation, and meiotic cell cycle. Localization evidence links the gene to the TORC1 complex, cell cortex, cell division site, membrane, cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal colony color, increased adhesion, decreased chitin deposition, increased polyploidy, delayed cell cycle progression, decreased cell fusion, absent budding, increased alkaline pH resistance, decreased necrotic cell death, increased mating response, increased starvation resistance, and absent spindle morphology. Studies of related genes in other species connect the family to nucleolar size regulation.