FLBA — Aspergillus fumigatus

Summary

AFU2G11180 (FLBA, flbA) in Aspergillus fumigatus encodes the developmental regulator FlbA, a protein with GTPase-activating (GAP) activity that contains RGS and DEP domains. This gene is associated with the negative regulation of GPCR signaling, conidiophore development, asexual sporulation, autolysis, and the regulation of sterigmatocystin biosynthesis and breakdown. It is linked to intracellular signal transduction, the pheromone response MAPK cascade, protein secretion, and responses to oxidative stress. FLBA localizes to the cytoplasm, nucleus, and internal side of the plasma membrane. Phenotypic associations include altered shmoo formation, mating response, pheromone sensitivity, endocytosis, vegetative growth, osmotic stress resistance, and sterile phenotypes. Studies of related genes in other species link the family to germination rate and reticulophagy.