ags2 — Aspergillus fumigatus

Summary

AFU2G11270 (ags2, also known as AfMOK12) in Aspergillus fumigatus encodes an alpha-1,3-glucan synthase (EC 2.4.1.183), a glycoside hydrolase family protein with starch synthase catalytic and carbohydrate-binding domains. The gene is associated with alpha-1,3-glucan and cell wall biosynthesis, ascospore wall and primary cell septum biogenesis, morphogenesis, and cell wall organization. Its product localizes to the ascus membrane, ascospore wall, plasma membrane at cell tips, division septum, and medial membrane band. The gene is linked to invasive pulmonary aspergillosis in a mouse model and to germination rate. Related genes in other species are associated with turgor pressure.