ffmA — Aspergillus fumigatus

Summary

AFU2G10550 (ffmA) on chromosome 2 of Aspergillus fumigatus encodes a putative C2H2 transcription factor (RfeC-like) with RNA polymerase II cis-regulatory region sequence-specific DNA binding and DNA-binding transcription factor activity, as well as zinc binding. The product belongs to the VerF-like and C2H2 zinc finger families. It is associated with hyphal growth, regulation of transcription by RNA polymerase II, and DNA-dependent transcription, and localises to chromatin and the nucleus. Studies of related genes in other species link the family to reduced virulence, though this has not been established for ffmA itself.