tor — Aspergillus fumigatus

Summary

AFU2G10270 (tor) on Aspergillus fumigatus chromosome 2 encodes a serine/threonine-protein kinase TOR, a member of the PI3/4-kinase family with FRB, FAT, FATC and HEAT-repeat domains. The enzyme exhibits histone H2A kinase activity, protein serine/threonine kinase activity, pre-rRNA binding and protein complex binding. It is associated with TORC1 and TORC2 complexes, nucleolar chromatin, and the ATR-ATRIP complex. The gene is linked to regulation of primary metabolism, DNA damage response signalling, positive regulation of cytoplasmic translation, downregulation of macroautophagy, siderophore biosynthesis, innate immunity, and meiotic DNA replication checkpoint control. Phenotypic associations include increased virulence, abnormal cell cycle progression, absent sporulation efficiency, altered carbon and nitrogen source utilization, and decreased polyploidy. Related genes in other species are linked to oxidative stress response, protein content and turgor pressure.