CCS1 — Aspergillus fumigatus

Summary

AFU2G09700 (CCS1, AfCCS1) on Aspergillus fumigatus chromosome 2 encodes a protein with SOD_Cu/Zn and HMA domains. The gene product exhibits superoxide dismutase copper carrier activity, copper binding, and metal binding, and is associated with superoxide metabolism, copper ion transport, cellular copper ion homeostasis, detoxification, and cellular response to metal. Localisation evidence links the protein to the mitochondrial inner membrane, cytoplasm, cytosol, and nucleus. AfCCS1 is associated with numerous phenotypes including abnormal cell cycle progression (premature G1/S transition, delayed G2/M and S phases, delayed metaphase), increased mitochondrial genome maintenance, abnormal mitochondrial and vacuolar transport, increased respiratory metabolism, decreased growth in exponential phase, abnormal redox state, decreased cold sensitivity, decreased apoptosis, abnormal cell wall morphology, and altered stress resistance (increased hydrostatic pressure and alkaline pH resistance, decreased radiation and X-ray resistance). Studies of related genes in other species connect it to unaffected pathogenicity.