MTM1 — Aspergillus fumigatus

Summary

AFU2G09250 (AfMTM1, MTM1) on chromosome 2 of Aspergillus fumigatus encodes a putative mitochondrial carrier protein of the Mtm1-like family. The product is annotated with glutathione transmembrane transporter, aspartate:glutamate proton antiporter, 2-oxoglutarate transporter, thiamin permease, glycine transporter, magnesium ion transporter, and thiamine diphosphate transporter activities, and is localised to the mitochondrial inner membrane. It is associated with pyridoxal phosphate transport, glutathione import into mitochondria, the malate-aspartate shuttle, cellular iron ion homeostasis, calcium signalling, hyphal growth, and detoxification. Phenotypic associations include delayed respiratory growth, abnormal colony colour, decreased nitrogen source utilisation, increased cell death, decreased spore germination, increased apoptosis, increased mitotic recombination, increased mutation frequency, and increased cell size. Studies of related genes in other species link the family to mitochondrial genome maintenance and carbon source utilisation.