PYRG — Aspergillus fumigatus

Summary

AFU2G08360 (PYRG) encodes a protein with orotidine-5'-phosphate decarboxylase and orotate phosphoribosyltransferase activities. The gene is associated with uracil anabolism, UMP anabolism, 'de novo' UMP biosynthesis, 'de novo' pyrimidine base anabolism, conidium germination, invasive growth, sporocarp development involved in sexual reproduction, DNA-mediated transformation, double-strand break repair, homologous recombination, N-glycan processing, GPI anchor anabolism, melanin anabolism, pigment anabolism, thiamin anabolism, the glyoxylate cycle, phagocytosis, and regeneration. It is linked to phenotypes including altered adhesion, biofilm formation, filamentous growth, nutrient uptake, autophagy, stress resistance, and chronological lifespan. The encoded protein localises to the cytosol. Related genes in other species link the family to pyrimidine auxotrophy and orotidine-5'-phosphate decarboxylase activity.