SIB2 — Aspergillus fumigatus

Summary

AFU2G07680 (symbol SIB2, also known as sidA) in Aspergillus fumigatus encodes an ornithine N5-monooxygenase (EC 1.14.13.196), a member of the Lys/Orn_oxygenase family that binds FAD/NAD, NADP+, iron and nucleotides. This gene is associated with siderophore metabolism, including ferrichrome and siderophore biosynthesis, as well as siderophore-iron and iron import into cells. It has been connected to cellular responses to iron ion starvation, oxidative stress, and iron homeostasis, along with asexual sporulation, germ tube formation, and tube formation. The gene is also linked to inflammatory and immune responses, ergosterol biosynthesis, amino acid biosynthesis, and nitric oxide storage. Studies of related genes in other species associate the family with reduced virulence and conditions such as pulmonary aspergillosis and fusarium ear blight.