SOK2 — Aspergillus fumigatus

Summary

AFU2G07900 (SOK2, also known as stuA) on chromosome 2 of Aspergillus fumigatus encodes a protein with a KilA/APSES-type helix-turn-helix DNA-binding domain. The gene is associated with sequence-specific DNA binding and transcription factor activity, and its product localises to the nucleus. SOK2 is linked to the positive regulation of conidiophore development, conidium formation, and asexual reproduction, as well as to sporocarp development, morphogenesis, and developmental processes. It has been connected to melanin and mycotoxin anabolism, cell wall polysaccharide biosynthesis, glycan and nucleotide-sugar metabolism, and cell adhesion. Associations also include mast cell degranulation, cytokine production, leukocyte adhesion, and regeneration. Related genes in other species link the family to flocculation, biofilm formation, filamentous growth, mating-type switching, adhesion, fermentative metabolism, and cell cycle progression.