BD — Aspergillus fumigatus

Summary

AFU2G07770 (BD, AfBD) encodes a small GTPase of the Ras-type family with GTPase activity and GTP binding, classified as EC 3.6.5.2. This Aspergillus fumigatus gene is associated with Ras protein signal transduction, regulation of conidium formation, spore germination, hyphal growth, invasive growth, mating, cell wall organization, cell polarization, and prenylation/protein farnesylation. It is linked to the inflammatory response, innate immunity, and immune response, as well as glucan and amino acid anabolism. The encoded protein localizes to the plasma membrane. Phenotypic associations include bipolar budding pattern, redox state, mating type switching, entry into G0, osmotic and oxidative stress resistance, nuclear export, pheromone production, protein transport, cell cycle progression, flocculation, and transposable element transposition. Studies of related genes in other species link the family to protein content and oxidative stress response.