AMT1 — Aspergillus fumigatus

Summary

AFU2G05880 (AMT1, also known as meaA) in Aspergillus fumigatus encodes an ammonium transporter family protein with ammonium channel activity and methylammonium transmembrane transporter activity. The gene is associated with ammonium and methylammonium membrane transport, import across the plasma membrane, and localisation to the plasma membrane, fungal-type vacuole, and Golgi complex. AMT1 is associated with host invasion, proteolysis, and numerous phenotypes including abnormal biofilm formation, increased virulence, increased sporulation, altered cell cycle progression, abnormal autophagy and pexophagy, decreased nitrogen source utilisation, and increased survival in stationary phase. The gene is also associated with abnormal filamentous growth, flocculation, respiratory metabolism, plasma membrane morphology, and nuclear size. Studies of related genes in other species link the family to protein content, phosphate content, and acid sensitivity.