EUG1 — Aspergillus fumigatus

Summary

AFU2G06150 (EUG1, also known as pdiA or AfPDI1) on chromosome 2 of Aspergillus fumigatus encodes a protein-disulfide isomerase (EC 5.3.4.1) with thioredoxin domains, catalysing disulphide bond formation in the endoplasmic reticulum. The gene is associated with protein folding in the ER, ER stress response, secretion, cellular response to oxidative stress, immune response and immune evasion. It is linked to numerous cellular phenotypes including abnormal colony shape, decreased anaerobic growth, delayed cytokinesis, abnormal septum formation, altered cell cycle progression, increased aneuploidy, and defects in nuclear fusion during mating. The product localises to the ER lumen. Related genes in other species connect the family to oxidative stress response and interactions with ERO1 and SSA1.