ATP17 — Aspergillus fumigatus

Summary

AFU2G05510 (ATP17) in Aspergillus fumigatus encodes the mitochondrial F1F0 ATP synthase subunit F (Atp17), a component of the F0 sector of the ATP synthase complex. The gene product possesses proton-transporting ATP synthase activity and hydrolase activity, and is localized to the mitochondrial inner membrane as part of the F1F0 complex. ATP17 is associated with proton motive force-driven ATP synthesis, proton motive force-driven mitochondrial ATP synthesis, and proton transmembrane transport. The gene has been linked to numerous phenotypes including decreased oxidative phosphorylation, absent anaerobic growth, abnormal vesicle distribution, decreased nucleophagy, abnormal endocytosis, decreased necrotic cell death, delayed cell cycle progression, increased survival in stationary phase, increased mitochondrial rho- mutation frequency, absent mitophagy, increased small molecule transport, increased cell death, absent mitochondrial genome maintenance, abnormal vacuolar transport, petite-negative status, abnormal peroxisomal morphology, decreased RNA modification, decreased apoptosis, decreased mitochondrial genome maintenance, increased lifespan, petite status, increased mitophagy, increased viability, decreased respiratory metabolism, abnormal endomembrane system morphology, decreased survival in stationary phase, abnormal mitochondrial genome maintenance, decreased mitophagy, increased apoptosis, and increased respiratory growth rate.