atrR — Aspergillus fumigatus

Summary

AFU2G04150 (atrR) on Aspergillus fumigatus chromosome 2 encodes a C6 transcription factor with DNA-binding transcription activator activity specific to RNA polymerase II. The gene is associated with the positive regulation of thiamin biosynthetic process, siderophore anabolism, reductive iron assimilation, sterol and ergosterol anabolism, sterol homeostasis, biofilm formation, hyphal growth, and hypersensitivity. It is also linked to RNA-dependent gene silencing, positive regulation of transcription and metabolism, and . The encoded protein localises to chromatin, membrane, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence and pulmonary aspergillosis, though these associations are not yet established for atrR itself.