HPD4 — Aspergillus fumigatus

Summary

AFU2G04200 (symbol HPD4, also known as AfHPD4) on chromosome 2 of Aspergillus fumigatus encodes a 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27), a metal-binding enzyme containing the 4OHPhenylPyrv_dOase and VOC domains. This gene is associated with tyrosine and L-phenylalanine breakdown, as well as pigment and melanin anabolism. Studies of related genes in other species, including Fusarium and Verticillium species, link the family to these same metabolic pathways.