ARG1 — Aspergillus fumigatus

Summary

AFU2G04310, designated AfARG1, encodes an argininosuccinate synthase (EC 6.3.4.5) with argininosuccinate synthase activity and ATP binding, and localises to the cytoplasm and cytosol. AfARG1 is associated with arginine anabolism, the urea cycle, and immune-related processes including macrophage activation, inflammatory response, IL-33 production, phagocytosis, and secretion. The gene has been connected to numerous phenotypes, including decreased mitochondrial genome maintenance, altered prion inheritance, reduced mitophagy and pexophagy, increased telomere length, abnormal cell shape and size, decreased freeze-thaw and alkaline pH resistance, and increased sporulation efficiency. It is also linked to protein content. Related genes in other species connect it to nitrogen source utilisation and haploinsufficiency.