CYB5 — Aspergillus fumigatus

Summary

AFU2G04710 (CYB5, AfCYB5) on chromosome 2 encodes a putative cytochrome b5 protein containing a Cyt_B5-like heme/steroid-binding domain. The gene is associated with acyl-lipid (8-3)-desaturase, (S)-2-hydroxy-acid oxidase, L-lactate dehydrogenase (cytochrome), and electron transfer activities, as well as heme binding and redox activity. It is linked to unsaturated and long-chain fatty acid anabolism, sterol and ergosterol anabolism, detoxification, hypersensitivity, homeostasis, and response to metal. The product localises to the ER membrane, mitochondrial envelope lumen, and mitochondria. Phenotypic associations include decreased respiratory metabolism and growth, abnormal mitochondrial morphology and genome maintenance, absent autophagy, altered replicative and chronological lifespan, increased heat sensitivity, decreased UV, desiccation and oxidative stress resistance, altered vegetative growth, and increased toxin resistance. Studies of related genes in other species link the family to oxidative stress response and metal resistance.