BIP1 — Aspergillus fumigatus

Summary

AFU2G04620 (symbol BIP1, also known as bipA, AfKAR2, AfGRP78, KAR2, GRP78, AfBIP1) on chromosome 2 of Aspergillus fumigatus encodes a member of the Hsp70 family of ATP-dependent molecular chaperones, possessing ATP hydrolase activity, protein translocase activity, and heat shock protein binding activity. The gene is associated with the unfolded protein response (UPR), including the IRE1 branch, the ERAD pathway, protein refolding, and protein localization in the endoplasmic reticulum. It is linked to carbohydrate anabolism, pseurotin A anabolism, fungal-type cell wall beta-glucan anabolism, secretion, chemotaxis, and immune and type 2 immune responses. The product localizes to the ER lumen, perinuclear and cortical ER, the ER chaperone complex, and the fungal biofilm matrix. Associations with phenotypes include increased adhesion, altered cell cycle progression, abnormal nuclear fusion during mating, increased aneuploidy and polyploidy, and altered cell death. Related genes in other species link the family to hydrogen peroxide content and oxidative stress response.