hmgA — Aspergillus fumigatus

Summary

AFU2G04220 (hmgA) on chromosome 2 of Aspergillus fumigatus encodes a homogentisate 1,2-dioxygenase (EC 1.13.11.5), a metal-binding enzyme that belongs to the homogentisate dioxygenase family and contains a cupin-like jellyroll domain. The gene is associated with the breakdown of both L-phenylalanine and tyrosine, as well as with pigment anabolism. Related genes in other species link the family to these same aromatic amino acid catabolic pathways.