hosA — Aspergillus fumigatus

Summary

AFU2G03810 (hosA, also known as AfHDA-2 or HDA-2) in Aspergillus fumigatus encodes a histone deacetylase with NAD-independent activity, specifically deacetylating histones H3 and H4 at multiple lysine residues (e.g., H4-K16, H3-K9). The product belongs to the His_deacetylse_1 domain family and is associated with several chromatin-modifying complexes, including the HDA1, Rpd3S, SHREC, and SET3C complexes. This gene is associated with the positive regulation of p38 MAPK signaling, filamentous growth in response to pH and starvation, heterochromatin island and rDNA heterochromatin assembly, centromeric silencing, and epigenetic downregulation of gene expression. It is also linked to host invasion, inflammatory response, and phenotypic switching.