FPR2 — Aspergillus fumigatus

Summary

AFU2G03870 (FPR2) on chromosome 2 of Aspergillus fumigatus encodes a peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) of the FKBP2/11 family, possessing PPIase_FKBP and PPIase domains. The product is associated with protein folding, reactive oxygen species anabolism, the inflammatory response, and cellular response to farnesol, and localises to the ER lumen, ER, and membrane. Phenotypic associations include altered growth rates (both increased and decreased exponential-phase growth, decreased vegetative growth), abnormal endomembrane system and vacuolar morphology, increased and decreased metal resistance, decreased acid pH resistance, decreased heat sensitivity, decreased oxidative stress resistance, altered competitive fitness, altered chemical resistance, and inviability or haploinsufficiency. Studies of related genes in other species link them to decreased freeze-thaw and starvation resistance, decreased respiratory growth, and increased heat sensitivity.