LEU3 — Aspergillus fumigatus

Summary

AFU2G03460 (LEU3, also known as AfLEU3, ZC282, or VAD-2) on chromosome 2 of Aspergillus fumigatus encodes a C6 transcription factor with a Zn2Cys6 DNA-binding domain and DNA-binding transcription activator activity. This gene is associated with siderophore metabolism, regulation of cellular response to iron ion starvation, riboflavin transport, valine anabolism, cellular response to basic pH, cellular response to iron ion starvation, cellular iron ion homeostasis, interaction with host, upregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus, amino acid anabolism, regulation of DNA-templated transcription, proteolysis, autophagy, DNA repair, filamentous growth, homeostasis, and DNA-dependent transcription. It localizes to both the cytoplasm and nucleus. Phenotypic associations include abnormal mitochondrial transport, absent meiosis, increased X-ray resistance, absent RNA accumulation, decreased pexophagy, decreased protein/peptide distribution, decreased meiotic recombination, increased silencing, increased flocculation, increased utilization of carbon source, decreased reticulophagy, increased respiratory growth, arrested cell cycle progression, abnormal mitochondrial genome maintenance, decreased mitophagy, decreased ionic stress resistance, absent utilization of carbon source, absent resistance to chemicals, abnormal liquid culture appearance, increased resistance to enzymatic treatment, decreased mitotic recombination, increased transposable element transposition, increased size of nucleolus, abnormal nuclear morphology, increased killer toxin