CLR6 — Aspergillus fumigatus

Summary

AFU2G03390 (CLR6, also known as rpdA) encodes a histone deacetylase, specifically an NAD-independent histone deacetylase with activity toward multiple histone H3 and H4 lysine residues, including H3-K9, H3-K14, H4-K5, H4-K8, H4-K12, and H4-K16. The gene is associated with chromatin silencing, heterochromatin island and rDNA heterochromatin assembly, centromeric silencing, and epigenetic downregulation of gene expression. It is linked to the regulation of phenotypic switching, filamentous growth in response to pH, starvation, and biotic stimuli, as well as asexual sporulation. The protein localizes to several chromatin-modifying complexes, including the Rpd3S, SHREC, SET3C, and Clr6-LE complexes, and is found in euchromatin and heterochromatin islands. Associations with cell cycle progression, mating type switching, flocculation, biofilm formation, and nutrient uptake have also been observed.