atrR — Aspergillus fumigatus

Summary

AFU2G02690 (atrR, also known as ZC131 or AfZC131) in Aspergillus fumigatus chromosome 2 encodes a Zn2Cys6 DNA-binding transcription factor with sequence-specific DNA binding activity. This gene is associated with siderophore anabolism, reductive iron assimilation, ergosterol anabolism, sterol anabolism, sterol homeostasis, biofilm formation, hyphal growth, and hypersensitivity. It is linked to positive regulation of transcription by RNA polymerase II and positive regulation of metabolism. The encoded product localises to the nucleus, cytosol, and membrane. Related genes in other species link the AtrR family to reduced virulence and pulmonary aspergillosis.