ASN1 — Magnaporthe oryzae 70-15

Summary

MoASN1 (MGG_00969) on chromosome 5 of Magnaporthe oryzae 70-15 encodes an asparagine synthase (glutamine-hydrolyzing) (EC 6.3.5.4), a member of the AsnB_N and Asn_synthase domain families, with ATP-binding and hydrolase activities. The gene is associated with L-asparagine biosynthesis and hyphal growth, and its product localises to the cytosol and nucleus. MoASN1 is associated with cell cycle progression (G1/S phase transition and metaphase arrest), chromosome segregation, spindle morphology, cytoskeleton organisation, RNA localisation and accumulation, telomere length, replicative lifespan, and prion inheritance. It is also linked to stress responses such as acquired and innate thermotolerance, cold sensitivity, hydrostatic pressure resistance, and heat sensitivity, as well as increased invasive growth, altered fermentative metabolism, and colony sectoring. Studies of related genes in other species link the asparagine synthase family to similar cellular and stress-associated phenotypes.