PEX14 — Magnaporthe oryzae 70-15

Summary

MGG_01028 (MoPEX14) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a protein containing a Pex14_N domain and a WH-like DNA-binding superfamily domain. The gene product is associated with signaling receptor binding and localizes to the peroxisome membrane, where it is linked to peroxisome matrix protein import docking, protein-peroxisome targeting, peroxisome fission, pexophagy, autophagy, morphogenesis, and sexual reproduction. MoPEX14 is associated with numerous phenotypes including absent peroxisomal transport and morphology, abnormal peroxisomal distribution, delayed meiosis, decreased mating response, increased hyperosmotic stress resistance, increased survival rate in stationary phase, and altered mitochondrial transport, genome maintenance, and mitophagy. Studies of related genes in other species link the PEX14 family to peroxisome biogenesis factors such as PEX1, PEX6, PEX7, PEX10, PEX12, and PEX13.