PTH2 — Magnaporthe oryzae 70-15

Summary

MGG_01099 (MoPTH2) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a peptidyl-tRNA hydrolase (EC 3.1.1.29), a member of the PTH2 family with a peptidyl-tRNA hydrolase II domain. The gene is associated with glyoxylate metabolism, the glyoxylate cycle, response to acetate, acetyl-CoA transport, glycerol anabolism, and rescue of stalled cytosolic ribosomes. Its product localises to the mitochondria, cytosol, and the external side of the mitochondrial outer membrane. MoPTH2 is associated with abnormal vegetative growth, decreased spore germination, increased apoptosis, altered mitochondrial and peroxisomal transport, abnormal redox state, increased mitophagy, decreased prion formation, and increased mutation frequency. It is also linked to turgor pressure and to the host plants Hordeum vulgare and Oryza sativa.