SLP1 — Magnaporthe oryzae 70-15

Summary

MoSLP1 (MGG_01236) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a Cdc20/Fizzy family protein containing WD40 repeats and possessing ubiquitin ligase activator activity, APC binding, mediator complex binding, histone deacetylase binding, transcription corepressor activity, histone binding, GTP binding, and phosphatidylinositol (3,5)-bisphosphate binding. The gene is associated with cell cycle regulation, including positive regulation of anaphase-promoting complex-dependent catabolic processes, meiotic cell cycle progression, and metaphase/anaphase transitions, as well as conidia and spore formation, innate immunity, ER-phagy, HOG response, and regulation of fatty acid anabolism. It localizes to the cyclosome, mitotic spindle, kinetochore, spindle pole body, chromatin, and transcription repressor complexes. The gene is linked to turgor pressure and numerous cell cycle and sporulation phenotypes. Studies of related genes in other species connect MoSLP1 to mitotic checkpoint control and anaphase progression.