MET2 — Magnaporthe oryzae 70-15

Summary

MoMET2 (MGG_01469) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a protein with homoserine O-acetyltransferase and deacetylcephalosporin-C acetyltransferase activities, belonging to the HAT_MetX-like and alpha/beta hydrolase families. The gene is associated with L-methionine biosynthesis, transsulfuration, homoserine metabolism, pigmentation, sporulation, and antibiotic anabolism, and its product localises to the cytoplasm and cytosol. Phenotypic associations include absent or decreased sporulation, autophagy, mitophagy, pexophagy, and reticulophagy, abnormal nuclear and vacuolar morphology, decreased viability, freeze-thaw resistance, desiccation resistance, metal resistance, and competitive fitness, increased chronological lifespan and chemical compound excretion, and abnormal protein/peptide modification and accumulation. Studies of related genes in other species link the homoserine O-acetyltransferase family to auxotrophy, altered metal and chemical resistance, and competitive fitness.