PP2A — Magnaporthe oryzae 70-15

Summary

MoPP2A (MGG_01690) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a protein phosphatase with protein serine/threonine phosphatase activity (EC 3.1.3.16), belonging to the PPA2-like and calcineurin-like phosphoprotein phosphatase families. The gene is associated with diverse biological processes including negative regulation of mitophagy, regulation of TORC1 signaling, pigmentation, cell shape regulation, and glycogen metabolism. It localizes to multiple cellular compartments such as the PP2A complex, nuclear periphery, mitochondrial outer membrane, mitotic spindle pole body, and chromatin. Phenotypic associations link MoPP2A to abnormal cell cycle progression, decreased apoptosis, altered pheromone sensitivity, and decreased resistance to chemicals and ionic stress. Studies of related genes in other species connect the family to reduced virulence.