CP1 — Magnaporthe oryzae 70-15

Summary

MoCP1 (MGG_02309) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a serine carboxypeptidase belonging to the peptidase S10 and alpha/beta hydrolase families. The gene is associated with proteolysis, chromatin silencing, and fHC assembly, and its product localises to the fungal-type vacuole, extracellular space, plasmalemma, and side of membrane. MoCP1 is linked to numerous cellular processes including autophagy, mitophagy, pexophagy, ribophagy, endocytosis, cytokinesis, nuclear fusion during mating, protein secretion, and prion inheritance. Phenotypic associations include altered cell death, increased aneuploidy, abnormal Golgi morphology, and changes in replicative lifespan and thermotolerance. Related genes in other species connect the family to apoplastic effector function and carboxypeptidase activities (EC 3.4.16.5 and 3.4.16.6).