BIP1 — Magnaporthe oryzae 70-15

Summary

MGG_02503 (MoBIP1) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an endoplasmic reticulum chaperone BiP, a member of the Hsp70 family with ATP hydrolase activity and protein translocase activity. This gene is associated with the IRE1 branch of the unfolded protein response, ERAD pathway, protein refolding, secretion, and fungal-type cell wall beta-glucan anabolism. It is linked to appressorium formation, spore germination, hyphal growth, host invasion, and secondary metabolism. Localisation evidence places the product in the ER lumen, perinuclear and cortical ER lumen, nuclear membrane, and extracellularly. Phenotypic associations include abnormal cell fusion, increased polyploidy and aneuploidy, altered cell cycle progression, increased adhesion, and abnormal autophagy and endocytosis. Studies of related genes in other species connect the family to oxidative stress response and hydrogen peroxide content.