CDC42 — Magnaporthe oryzae 70-15

Summary

MGG_02731 (CDC42) in Magnaporthe oryzae 70-15 encodes a Ras-like protein (ced-10) belonging to the small GTPase Rho family, with GTPase activity, GTP and GDP binding, protein kinase binding, and signaling adaptor activity. This gene is associated with the regulation of cell morphogenesis, bipolar cell growth, budding cell isotropic bud growth, and cell growth mode switching from budding to filamentous. It is linked to the positive regulation of 1,3-beta-D-glucan biosynthetic process, cell wall modification, septin ring organization, and regulation of exocytosis and vesicle-mediated transport. The product localizes to the hyphal tip polarisome, Spitzenkörper, exocytic vesicle, and 1,3-beta-glucan synthase complex. Related genes in other species are linked to increased virulence (hypervirulence) and the Cdc42 GTPase complex.