PAN3 — Magnaporthe oryzae 70-15

Summary

MGG_02939 (PAN3, MoPAN3) on chromosome 7 of Magnaporthe oryzae 70-15 encodes a protein with a Pan3_CK domain, a Znf_CCCH motif, and a protein kinase domain, and is annotated with poly-A binding, protein kinase activity, zinc binding, and ATP binding. The gene is associated with the PAN complex and P-body localisation, and with biological processes including appressorium maturation, nuclear-transcribed mRNA poly(A) tail shortening, mRNA processing, detoxification, and autophagy. Phenotypic associations include decreased spore germination rate, increased autophagy and mitophagy, increased sporulation efficiency, increased ionic stress resistance, decreased alkaline pH and hydrostatic pressure resistance, abnormal cell cycle progression through G1 and G2/M phases, and increased mutation frequency. Related genes in other species link PAN3 to mRNA deadenylation and cell cycle control.