MOB1 — Magnaporthe oryzae 70-15

Summary

MGG_03151 (MoMOB1) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a maintenance of ploidy protein (MOB1) belonging to the MOB kinase activator family, with protein kinase activator activity, protein kinase activity, and metal binding. The gene is associated with the RAM/MOR signaling network, mitotic exit, cytokinesis, division septum assembly, septum digestion, actin cortex stabilization, lipid raft organization, filamentous growth, biofilm formation, bipolar cell polarity, and response to neutral pH. It localizes to spindle pole bodies, the hyphal tip, bud tip, bud neck, medial ring, and cross wall. MoMOB1 is linked to rice blast disease and has been connected to numerous phenotypes including abnormal cytoskeleton morphology, absent septum formation, delayed cell cycle progression, abnormal chromosome segregation, defective sporulation, and loss of hyperosmotic stress resistance.