CLM2 — Magnaporthe oryzae 70-15

Summary

MoCLM2 (MGG_03352) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a 3-hydroxyphenylacetate 6-hydroxylase, a cytochrome P450 family protein with monooxygenase, oxidoreductase, heme-binding and iron-binding activities. The gene is associated with demethylation, sporulation, hyphal growth, mitophagy, and mycotoxin and penicillin production. It is linked to numerous phenotypes including decreased micronucleophagy and ribophagy, abnormal plasma membrane morphology, increased cell death, arrested vegetative and exponential-phase growth, decreased invasive growth and shmoo formation, increased fermentative metabolism, altered cell cycle progression, and decreased utilization of iron and phosphorus sources. The gene is also connected to membrane localization and to related genes including FMAG and several ERG family members. Studies of related genes in other species link it to cytochrome P450 sterol 14α-demethylase domains and to protein content traits.