ATG4 — Magnaporthe oryzae 70-15

Summary

MGG_03580 (ATG4, MoATG4) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a cysteine protease of the peptidase C54 family with Atg8-specific protease and thiol endopeptidase activities. The gene is associated with autophagy, mitophagy, aggrephagy, autophagic cell death, programmed cell death, protein processing and transport, membrane targeting, asexual sporulation, spore germination, appressorium formation, cell differentiation, methylation, homeostasis, and bioluminescence. The encoded protein localises to the phagophore assembly site, cytoplasm, cytosol, nucleus, and mitochondria. ATG4 is linked to blast disease in rice and to traits including turgor pressure. Phenotypic associations include absent autophagy, mitophagy, pexophagy, nucleophagy, endocytosis, protein secretion, filamentous growth, and cell death; delayed autophagy and cell cycle; increased ionic stress resistance and mating response; and decreased colony size and cold sensitivity.