GCN5 — Magnaporthe oryzae 70-15

Summary

MGG_03677 (MoGCN5) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein with GNAT and bromodomain family domains. The enzyme exhibits histone H3K9, H3K14, H3K18, and H4K12/K16 acetyltransferase activities, as well as histone crotonyltransferase activity, and is annotated as a transcriptional coactivator and chromatin adaptor. MoGCN5 is associated with protein acetylation, carbon catabolite repression, asexual reproduction, appressorium formation, melanin anabolism, macroautophagy, programmed cell death, and DNA repair-dependent chromatin remodeling. It localizes to the nucleus, cytoplasm, chromatin, and several complexes including the ADA and SAGA complexes. The gene is linked to blast in rice and Hordeum vulgare. Studies of related genes in other species connect the family to hypervirulence and loss of pathogenicity.