TNG — Magnaporthe oryzae 70-15

Summary

MGG_03911 (TNG, MoTNG) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a serine/threonine-protein phosphatase of the PPA2-like family, with protein phosphatase activity (EC 3.1.3.16) and metal binding. The gene is associated with regulation of TORC1 signaling, cell adhesion involved in biofilm formation, filamentous growth in response to chemical stimulus, neutral pH, and heat, as well as regulation of cell shape, actin cytoskeleton organization, and fungal-type cell wall organization. It is linked to negative regulation of the DNA damage checkpoint and the acetoacetate-mevalonate pathway, and to positive regulation of non-homologous end joining. Associations include increased virulence, altered cell cycle progression (including G2 phase delay and decreased metaphase/anaphase duration), abnormal pheromone sensitivity, absent alkaline pH resistance, and altered cell death rates. The protein localizes to the nucleus, cytoplasm, chromatin, nuclear periphery, and PP2A/PP4 complexes.