CDC7 — Magnaporthe oryzae 70-15

Summary

MoCDC7 (MGG_04100) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a protein with a protein kinase domain, serine/threonine kinase active site, and ARM-type fold, and is annotated with protein serine/threonine kinase activity, MEKK activity, ERK1, and ATP binding. The gene is associated with JNK cascade, p38 cascade, pheromone response MAPK cascade, MAPK cascade, intracellular signal transduction, programmed cell death, macroautophagy, hyphal growth, contractile ring assembly, septum digestion after cytokinesis, activation of mitotic division septum assembly, regulation of establishment or maintenance of bipolar cell polarity regulating cell shape, ergosterol anabolism, and protein localization to cell division site. It localizes to the cell division site, division septum, mitotic and meiotic spindle pole bodies, cell tip, and cytoplasm. Studies of related genes in other species link the family to non-specific serine/threonine protein kinase activity and, in some cases, unaffected pathogenicity.