AMYC — Magnaporthe oryzae 70-15

Summary

MoAMYC (MGG_04377) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a Rho-type GTPase-activating protein 1 containing a RhoGAP domain and a Znf_LIM domain, with GAP activity and small GTPase binding. This gene is associated with appressorium formation, hyphal growth, cell wall biogenesis and organization, actin cytoskeleton organization, regulation of bipolar cell polarity and cell shape, negative regulation of the cell integrity MAPK cascade, defense response, homologous recombination, and signal transduction. It localizes to the cell cortex, cell tip, division septum, and sites of polarized growth. Phenotypic associations include abnormal bipolar budding, filamentous growth, cell fusion, mating efficiency, chitin deposition, and autophagy, as well as decreased adhesion and necrotic cell death. Studies of related genes in other species link the family to Rho1p, Cdc42p, and TORC2 signaling.