tpc1 — Magnaporthe oryzae 70-15

Summary

MGG_04483 (tpc1) in Magnaporthe oryzae 70-15 on chromosome 1 encodes a mitochondrial thiamine pyrophosphate carrier 1, a member of the mitochondrial carrier family with transmembrane domains. The protein exhibits multiple transporter activities, including thiamine diphosphate, coenzyme A, ATP/ADP, and PAPS transmembrane transport, and is localised to the mitochondrial inner membrane. This gene is associated with mitochondrial adenine nucleotide and thiamine pyrophosphate transport, regulation of mitochondrial membrane permeability, and responses to cold and salicylate. It is linked to host invasion, calcium signalling, morphogenesis, and lipid metabolism. Phenotypic associations include altered nitrogen source utilisation, abnormal G1 cell cycle progression, increased replicative and chronological lifespan, auxotrophy, and changes in competitive fitness and chemical resistance. Studies of related genes in other species connect the family to reduced virulence and decreased oxidative stress resistance.