ARG4 — Magnaporthe oryzae 70-15

Summary

MoARG4 (MGG_04503) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an ammonium-dependent carbamoyl phosphate synthetase, a large-subunit enzyme with multiple ATP-grasp and carbamoyl-phosphate synthase domains. The gene product is associated with pyrimidine nucleotide anabolism, arginine anabolism, the urea cycle, glutamine metabolism, and de novo UMP biosynthesis. It is linked to defense response and appressorium formation, and localizes to mitochondria, the cytoplasm, and nucleus. Associations with numerous phenotypes include altered cell death, lifespan, nutrient uptake, mitochondrial transport, stress resistance, sporulation, and pseudohyphal growth. The gene is also associated with aspartate carbamoyltransferase, GMP synthase, and glutaminase activities, and binds amino acids, ATP, and metals.