SEC61 — Magnaporthe oryzae 70-15

Summary

MoSEC61, encoded by the MGG_04856 gene on chromosome 3 of Magnaporthe oryzae 70-15, is the alpha subunit of the Sec61 protein transporter complex. The gene product possesses peptide transmembrane transporter activity, signal sequence receptor activity, protein translocase activity, and ribosome binding. MoSEC61 is associated with a wide range of biological processes, including SRP-dependent and posttranslational protein targeting to the ER, protein insertion and dislocation from the ER, secretion, ER-phagy, and cellular homeostasis. It is also linked to appressorium formation, spore germination, hyphal growth, morphogenesis, host invasion, innate immunity, and immune evasion. Additionally, MoSEC61 has been associated with photosynthesis, the TCA cycle, and turgor pressure, and is localized to the ER membrane, plasma membrane, extracellular vesicles, and fungal-type vacuoles.