VPS35 — Magnaporthe oryzae 70-15

Summary

MGG_05089 (MoVPS35) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a vacuolar protein sorting-associated protein 35 containing a Vps35_C domain. The gene is associated with retrograde transport from endosome to Golgi, intracellular protein transport, vesicle transport, secretion, autophagy, pexophagy, and lipid homeostasis. It is linked to appressorium-mediated host invasion and host invasion, as well as hyphal growth, ascospore formation, and NO storage. Localisation evidence connects the product to the late endosome, endosome, and cytosol. Phenotypic associations include absent sporulation and mitophagy, decreased spore germination rate, abnormal autophagy and endocytosis, increased ionic stress resistance, and altered adhesion and nutrient uptake. Related genes in other species link the VPS35 family to the retromer complex.