VPS9 — Magnaporthe oryzae 70-15

Summary

MGG_05379 (MoVPS9) on chromosome 1 of Magnaporthe oryzae 70-15 encodes vacuolar protein sorting-associated protein 9, a member of the Vps9 and CUE domain families. The product binds ubiquitin and small GTPases, and is associated with endocytosis, vesicle transport, and autophagy. It localises to endocytic vesicles and the cytosol. MoVPS9 is linked to blast disease in rice (Oryza sativa). The gene has been connected to numerous cellular processes including protein transport, endocytosis, vacuolar transport, autophagy, cytokinesis, cell cycle progression, meiosis, and stress responses such as resistance to hyperosmotic stress, hydrostatic pressure, alkaline pH, ionic stress, and UV. It is also associated with abnormal spore wall formation, protein secretion, and entry into G0 stationary phase. Related genes in other species link it to guanine nucleotide exchange factor activity and calcium sensitivity.