GTR2 — Magnaporthe oryzae 70-15

Summary

MoGTR2 (MGG_05694) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a GTP-binding protein belonging to the RagC/D and Gtr1_RagA family, with GTPase activity, GTP binding, and protein serine/threonine kinase activator activity. The gene is associated with TOR signaling, negative regulation of autophagy, cellular response to starvation, asexual reproduction, cell growth, and negative regulation of mitotic-to-meiotic cell cycle switching. The product localizes to the Gtr1-Gtr2 GTPase complex, fungal-type vacuole membrane, endomembrane system, cytosol, and nucleus. Phenotypic associations include altered cell death rates, absent vacuolar morphology, abnormal replicative lifespan, increased hydrostatic pressure and alkaline pH resistance, decreased meiosis and fermentative metabolism, and increased entry into G0 stationary phase. Studies of related genes in other species link the family to acid sensitivity and oxidative stress response.