ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_05746) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an ABC transporter with ATP hydrolase activity, heme binding, and transmembrane transporter activities for cadmium ions, phytochelatins, and xenobiotics. It is associated with vacuolar membrane localization, heme export from vacuole to cytoplasm, glutathione and PC2 import into vacuole, cellular detoxification of cadmium ions, response to toxic substances, host invasion, cell wall biogenesis, filamentous growth in response to starvation, secondary metabolism, and regulation of cell growth. The gene is also linked to siRNA-mediated post-transcriptional gene silencing, transposition, retrotransposition, homotypic vacuole fusion, and cichorine anabolism. Phenotypic associations include altered vacuolar morphology and distribution, decreased hyperosmotic and hypo-osmotic stress resistance, abnormal cell cycle progression, increased pexophagy, and changes in endocytosis rate and colony color.