FDH3 — Magnaporthe oryzae 70-15

Summary

MGG_06011 (FDH3, MoFDH3) in Magnaporthe oryzae 70-15 on chromosome 3 encodes a protein with alcohol dehydrogenase family domains and multiple enzymatic activities, including S-(hydroxymethyl)glutathione dehydrogenase, hydroxymethylfurfural reductase, and aldo-keto reductase activities. The gene is associated with furaldehyde and formaldehyde metabolism, xylitol and D-xylose catabolism, and detoxification processes. It has been linked to rice blast, and its product localizes to the cytoplasm, mitochondria, nucleus, and fungal biofilm matrix. Associations with abnormal cell cycle progression, increased filamentous growth, decreased anaerobic growth, increased thermotolerance, altered colony appearance, and changes in carbon source utilization have been reported. The gene is also associated with turgor pressure and homeostasis. Studies of related genes in other species link the family to acid pH resistance and formaldehyde dehydrogenase activity.